Automated analysis of contractile force and Ca transients in engineered heart tissue
نویسندگان
چکیده
Andrea Stoehr,* Christiane Neuber,* Christina Baldauf, Ingra Vollert, Felix W. Friedrich, Frederik Flenner, Lucie Carrier, Alexandra Eder, Sebastian Schaaf, Marc N. Hirt, Bülent Aksehirlioglu, Carl W. Tong, Alessandra Moretti, Thomas Eschenhagen, and Arne Hansen Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany; Texas A&M Health Science Center College of Medicine, Department of Medical Physiology, and Scott & White Healthcare Department of Medicine/Cardiology Division, Temple, Texas; Klinikum rechts der Isar-Technische Universität München, I. Medical Department-Cardiology, Ismaninger Straße, Munich, Germany; and DZHK (German Center for Cardiovascular Research)-partner site Munich Heart Alliance, Munich, Germany
منابع مشابه
Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.
Contraction and relaxation are fundamental aspects of cardiomyocyte functional biology. They reflect the response of the contractile machinery to the systolic increase and diastolic decrease of the cytoplasmic Ca(2+) concentration. The analysis of contractile function and Ca(2+) transients is therefore important to discriminate between myofilament responsiveness and changes in Ca(2+) homeostasi...
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